UC San Diego
Section of Neurobiology
Novel axon regeneration pathways in C. elegans
Friday, January 11
12 PM
RRI 101
Abstract: Using single axon injury assay in C. elegans, we systematically screened the function of >1200 selected C. elegans genes, based on their orthology to human genes and potential neuronal function or known biochemical role (Chen et al., Neuron 2011; Kim et al., 2018). We identified numerous axon regeneration pathways. Among them, we have elucidated signaling pathways for DLK-1 MAP kinases, and characterized rapid cellular dynamics in response to axon injury. In this talk, I will describe new findings from the continued genetic screening, including several RNA binding factors.
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