Sunday, October 22, 2017

This week on campus - 10/23-29

Climate Change: Where Are We and Where Do We Go From Here?, 10/24

USC Stem Cell Seminar | April Pyle, UCLA—"Defining the origins and function of human pluripotent stem cell derived skeletal muscle stem cells using in vivo human myogenesis", 10/24

Biotech Entrepreneurship | From Movies to Medicine: How Story Powers Everything, 10/26 [HSC]

Pause for Paws - Visiting Therapy Dogs, 10/26

Cardinal & Gold: Haunted Hay Ride, 10/27

Post-Doc Opportunity in the Stevens Lab

The Stevens Lab at the Bridge Institute at USC is looking to recruit 2 postdoctoral fellows/researchers to determine the 3-dimensional structure of the human pancreatic beta cell and to integrate digital arts and sciences.  These exciting and pioneering areas are at the forefront of biological discovery and part of the Pancreatic Beta Cell Consortium and World Building Media Lab at USC.  The Stevens Lab is interested in applicants from a broad range of backgrounds including chemistry, biology, computer science, and cinema.

To qualify, the applicant must hold a PhD in fields related to cell biology, molecular biology, structural biology, chemistry or other related biological or chemistry field, or any concentration/degree from cinematic arts and computer science. The candidates should be highly motivated and interested in being involved in a team oriented, highly collaborative, integrated project with high impact outcomes.  Individuals will be uniquely trained to become the next generation of leaders in the exciting area of convergent arts and sciences and will be highly competitive in future faculty recruitments globally.  Applicants should apply to by December 31st, 2017.

CODHy World Congress 2018 – Program Highlights!

For full-size version, click here.

Partek Software Onsite Training at USC, Nov. 8-9 2017

Thursday! Biotechnology Entrepreneurship-- From Movies to Medicine: How Story Powers Everything

The Top Science Careers Employers of 2017 - A survey of almost 7,000 scientists

Read the full article here.

Monday, October 16, 2017

Bridge Institute ChemBio Seminar | Alain Milon | October 18th at TRF 120

Alain Milon, Ph.D.
Institut de Pharmacologie et de Biologie Structurale (IPBS) Toulouse,
Department of Structural Biology and Biophysics

Title: NMR Analyses of the Structure and Dynamics of Klebsiella Pneumoniae OmpA Transmembrane Domain

Wednesday, October 18
2:00 pm
TRF 120

The transmembrane domain of kpOmpA possesses four long extracellular loops which exhibit substantial sequence vari¬ability throughout OmpA homologues in Enterobacteria. These loops are responsible for the immunological properties of the protein, such as cellular and humoral recognitions. Using liquid state NMR we have determined the 3D structure of kpOmpA in DHPC micelles (M. Renault et al., J. Mol. Biol. 2009). In a micellar environment, a complex dynamical behav¬ior has been observed: a rigid barrel core, ms motion at the micellar-water interface, and sub-ns motions within the loops. Using 1H and 13C detected solid state NMR relaxation measurements and proteolysis experiments, we have demonstrated the persistence of this complex motional behavior in E. coli polar lipid bilayers (I. Iordanov et al., Biochim. Biophys. Acta, 2012; O. Saurel et al., J Amer. chem. Soc., 2017). Using single molecule force spectroscopy we have shown that kpOmpA is able to unfold and refold reversibly its β-barrel core (P. Bosshart et al., Structure 2012). Finally, relaxation violated coher¬ence transfer NMR spectroscopy on Alanine residues provided an accurate determination of order parameters in the loops and barrel residues. These results provide a unique description of internal motion within a membrane protein and allow illustrating the power of liquid and solid state NMR.

The Scientific Community is Invited