Thursday, September 18, 2014

13 Dishes to Eat to Call Yourself an Angeleno

Whether you were born here or you're a recent transplant, you can't call yourself an Angeleno until you've tried all of these at least once.

Photo by Philippe, the Original

Link to Zagat article

Genome-wide Studies of DNA Structure, Function, and Evolution - BISC Intersection Seminar

BISC Inter-Section Seminar

A series of presentations highlighting ongoing research by your colleagues in
Molecular & Computational Biology, Human & Evolutionary Biology, Neurobiology, and Marine & Environmental Biology, as well as guest lecturers that span sectional interests.

"Genome-wide Studies of DNA Structure, Function, and Evolution"

Remo Rohs
Molecular & Computational Biology
Faculty profile

Where? Hedco Neurosciences (HNB) 107
When? Thursday 18 September 2014 @ 4:00 PM
Social hour to follow in the HNB Conference room


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The Secret Life of Bacteria

Get to know the tiny beings that live all around us—and how USC researchers are understanding and harnessing their powers.

Link to story

The Rise of Troy

USC Village will reshape how generations of Trojans live and learn on campus.

Link to story

Synergy Corporate Housing's September 2014 Newsletter (Issue 5)

Link to Newsletter

ChIP-seq: unleashing its full potential through data integration - Computational Biology Colloquium

Computational Biology Colloquium

“ChIP-seq: unleashing its full potential through data integration”

Hongkai Ji
Department of Biostatistics
Johns Hopkins University
Bloomberg School of Public Health

Thursday, September 18, 2014
2:00 PM
RRI 101
Hosts:  Ting Chen

One major goal of functional genomics is to comprehensively characterize the regulatory circuitry behind coordinated spatial and temporal gene activities. With the ability to map genome-wide transcription factor binding sites and histone modifications, ChIP-seq has quickly become an indispensable tool for studying gene regulation. Despite its unprecedented power, a number of challenges must be overcome before one can take full advantage of this high-throughput technology. First, ChIP-seq is increasingly used for analyzing dynamic changes of regulatory circuitry across different biological contexts (i.e., different cell types, time points, etc.). The conventional methods for analyzing data for one protein in one cell type cannot meet the emerging needs for characterizing quantitative and synergistic changes of DNA binding of multiple proteins between different conditions. New methods are required for dealing with the exponentially growing number of multi-protein combinatorial patterns, and for evaluating the statistical significance given the background biological and technical variation. Second, ChIP-seq is high-throughput with respect to analyzing the whole genome, but low-throughput with respect to analyzing gene regulation in a large number of biological contexts. New strategies need to be developed to better utilize ChIP-seq data originally collected from one biological system to gain insight into gene regulation in other biological systems or diseases. Third, ChIP-seq data also contain information on allele-specific binding (ASB). However, applying ChIP-seq to study ASB often suffers from low statistical power due to the limited number of reads mapped to heterozygote SNPs. In this talk, I will demonstrate that the problems above may be approached computationally by developing new statistical methods for jointly analyzing multiple ChIP-seq datasets and methods for integrating ChIP-seq data with enormous amounts of gene expression data in Gene Expression Omnibus (GEO).