Thursday, May 5, 2016

Post Doctoral Position Available at USC

USC Prof., Kelvin J. A. Davies, is looking for a motivated post-doctoral fellow to join his lab at the University of Southern California to study stress adaptation, protein oxidation & protein degradation
focusing on signal transduction pathways for regulation of the Proteasome and the mitochondrial Lon protease in oxidative stress.

Protease subunits and regulators are differentially expressed and exhibit differential binding/activities during stress. The Davies lab. is studying the mechanisms by which protein turnover and stress resistance are regulated during reversible adaptation.

Graduating Ph.D. students or recent Ph.D.’s with skills in biochemical methods and molecular biology techniques are encouraged to apply.  Interested candidates should contact Kelvin Davies directly by e-mail at kelvin@usc.edu.

Tuesday, May 3, 2016

Gerontology Colloquium | "Distinguishing physiological from chronological brain age..."

Thursday, May 5, 2016
12 noon, GER 224

Army Research Laboratory (ARL) - Distinguished Postdoctoral Fellowships

I ask your assistance in forwarding this message to graduate students in your department informing them of an outstanding fellowship opportunity with the Army Research Laboratory (ARL). The ARL Distinguished Postdoctoral Fellowship provides recipients the opportunity to pursue independent research while working alongside some of the nation's best scientists and engineers.

The Army Research Laboratory invites exceptional young researchers to apply for the ARL Distinguished Postdoctoral Fellowship. Applicants must display extraordinary ability in scientific research and show clear promise of becoming outstanding leaders. Successful candidates will have tackled a major scientific or engineering problem during their thesis work or will have provided a new approach or insight, as evidenced by a recognized impact in their field.

Eligibility criteria
Applicants must have completed all the requirements for a Ph.D. or Sc.D. degree in the physical sciences, life sciences, computational sciences, behavioral sciences, or engineering and must be within three years from the date of their degree at the time of application.
Selected fellows must pass a Department of Defense clearance process, requiring a background security investigation.
Applicants must demonstrate exceptional qualifications with respect to academic and scholarly achievement, as evidenced by research and publication.
Fellowship terms and benefits
Stipend - $100,000 annually
Health insurance (including dental and vision)
Paid relocation and a professional travel allowance
Appointments are for one year renewable for up to three years based on performance.

Fellowship appointments require a full-time commitment to the research program at ARL, and Fellows must be in residence at ARL during the entire period of the appointment.

More detailed information and an online application can be found at http://sites.nationalacademies.org/PGA/Fellowships/ARL.

Questions should be directed to the NRC at 202-334-3560 (phone) or ARLDPF@nas.edu.

Thank you for your assistance.

Sincerely yours,

H. Ray Gamble
Director, Fellowship Programs Office
National Academies of Sciences, Engineering, and Medicine
500 Fifth Street NW
Washington, DC 20001

Tuesday, April 26, 2016

Fulbright Info Session for Students

On Tuesday, May 10, 2016 from 11:30am– 1:30pm in Hedco Neurosciences Building Auditorium (HNB 100) representatives from the Institute of International Education, the organization that oversees the Fulbright, will talk about the program.

Increasing Openness & Reproducibility in Quantitative Research

The Office of Research and the Center for Open Science (COS) is hosting a workshop on Increasing Openness & Reproducibility in Quantitative Research on Monday, May 2nd, from 1-4 PM at the Gerontology Auditorium.

CB Colloquium | "Why don't transcription factors get lost?"

Barak Cohen
Washington University in St. Louis,
Department of Genetics

Abstract: The majority of signals from human genetic studies reside in non-coding DNA. Presumably, a large fraction of these variants exert their effects by influencing the functions of cis-regulatory elements. An important goal is to understand the sequence features that comprise cis-regulatory elements to the point where we can predict the effects of sequence variants on gene expression. Transcription Factor Binding Sites (TFBS) are key components of cis-regulatory elements, however, because TFBS are short, degenerate sequences they occur millions of times in mammalian genomes. This leads to a major problem: The vast majority of sequences that match TFBS are non-functional. My lab is studying the sequence determinants that specify active from inactive instances of TFBS. Some of these features include general sequence properties such as the local GC-content or intrinsic shape of DNA, while other features specify the cooperative interactions between TFs. We aim to develop quantitative models that discriminate active from inactive occurrences of TFBS and to use these models to understand the impact of genetic variation in non-coding DNA.

Thursday, April 28, 2016
2:00 PM
RRI 101

Host:  Remo Rohs


MB Seminar Series | "The genetic basis of non-genetic heterogeneity”

Mark Siegal
New York University,
Department of Biology,
Center for Genomics and Systems Biology

Abstract: Genetically identical cells growing in the same environment often display striking cell-to-cell heterogeneity in gene expression and other traits. Such heterogeneity is clinically important, as it is seen in microbial responses to antibiotics and in tumor cells. Nonetheless, molecular mechanisms that promote or suppress heterogeneity are poorly understood, particularly in eukaryotic organisms. We use the model eukaryote and opportunistic pathogen Saccharomyces cerevisiae (budding yeast) to study these mechanisms. I will present our work using high-throughput morphometric analysis of individual yeast cells to identify genes controlling the amount of variation in cell shape. I will also present our work on a form of evolutionarily adaptive heterogeneity in yeast. We developed a highly parallel, time-lapse microscopy assay to monitor variable protein expression, growth rate and survival outcomes of tens of thousands of yeast microcolonies simultaneously. Genetically identical cells display high variation in growth rate, and slow growth correlates with higher expression of stress-protective gene products and with higher tolerance of acute heat stress. Thus, heterogeneity can serve as a bet-hedging mechanism against environmental uncertainty. I will present our work to dissect the molecular mechanism of bet hedging and to map natural variation in growth strategies across yeast strains.

Friday, April 29, 2016
12:00 PM
RRI 101

Host: Ian Ehrenreich