Dr. Matthew J. Simpson
Professor, Queensland University of Technology, Science & Engineering, Mathematical Sciences, Applied & Computational Mathematics
Research Website
Mathematical and experimental models of cell invasion with fluorescent cell cycle indicators
Thursday, Oct. 31, 2 PM, RRI 101
Abstract: Fluorescent cell cycle indicators, such as FUCCI, allow us to visualize the cell cycle in individual cells. FUCCI reveals real-time information about cell cycle dynamics in individual cells, and can be used to explore how the cell cycle relates to the location of cells, local cell density, and different microenvironments. In this talk I will describe how FUCCI technology can be incorporated into continuum and discrete models of cell invasion. Using experimental data from two-dimensional cell invasion assays with FUCCI-transduced melanoma cells, we show how mathematical models can be used to predict key features of the experiments. The models we present are also amenable to travelling wave analysis, and some key highlights of this analysis will also be presented and discussed.
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