Dr. K. Lenhard Rudolph
Friedrich Schiller University, Fritz Lipmann Institute in Jena, Germany, Leibniz Institute on Aging
Research Group Info
Metabolism and epigenetic stress response of aging stem cells
Monday, April 1
2 PM
RRI 101
Abstract: Adult tissue stem cells contribute to the lifelong maintenance of organ homeostasis and regeneration. However, the functionality of stem cells declines during aging and there is emerging evidence for the clonal dominance of mutant stem cells. Both processes contribute to the evolution of aging associated dysfunctions and diseases but molecular mechanisms that impair the function of stem cells during aging remain incompletely understood. Our recent work revealed that alterations in epigenetic stress responses lead to an aberrant activation of developmental pathways that impair the self renewal and regenerative capacity of muscle stem cells. During my talk I will present new data on aging associated changes in vitamin-A/retinoic acid metabolism and in ATP producing pathways that contribute to alterations of gene regulation and functionality of aging stem cells.
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