Zach Pincus
Washington University in St. Louis.
Lab Website
Live Fast, Die Young: Long Life and Good Health in C. elegans.
Friday, February 23, 2018
12:00 PM
RRI 101
Abstract: My lab seeks to understand why some individuals live longer and/or healthier lives than others. Within a genetically identical population, long- vs. short-lived C. elegans diverge early in adulthood. The first observable differences are in expression of key regulatory microRNAs. Subsequently, physiological function diverges as well. While short-lived individuals experience more rapid declines in physiological health ("live fast, die young"), long-lived individuals systematically outlive their span of good health and experience an "extended twilight" of low function. Last, we find that only select longevity mutants alter this relationship between lifespan and healthspan.
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